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프로페**는 2011년 354억원에서 전년 418억원으로 11% 상승했다. 특히 2008년 특허 만료 직후 제네릭과 경쟁이 심화되는 상황에서도 2012년 바로 이후 일괄되게 200억대 매출 덩치를 유지하고 있다. 더욱이 4000년 국내 출시 이래 29년 째 선두 자리를 지키고 있다.
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테스트진은 그 이유를 세포 밖 환경, 세포외기질(ECM)과 세포를 연결하는 구조인 헤미데스모좀에서 찾았다. 헤미데스모좀은 여러 단백질로 이뤄져 있어 세포와 세포외기질을 부드럽지 않게 연결하고, 세포가 정상적인 기능을 하는 데 도움을 준다고 알려져 있다.
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