You should never vacuum rodent droppings in your attic because vacuuming can send contaminated particles into the air

https://augustnpln641.westhavenscope.com/posts/how-escondido-s-canyons-and-creeks-push-roof-rats-into-local-attics-2

You should never vacuum rodent droppings in your attic because vacuuming can send contaminated particles into the air and raise the risk of exposure to rodent-borne diseases.